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Despite its common use in many Asian countries as a skin lightening agent, efficacy in skin lightening of IV glutathione remains unclear due to the lack of human clinical trials evaluating the efficacy

Skin types that benefit most from GHK-Cu as a retinoid alternative include rosacea-prone, post-procedure, eczema-affected, and mature skin that reacts poorly to retinol

While results from IV ALA studies are consistently positive, the picture is more mixed when it comes to oral-only supplementation: A four-year randomized trial found no significant improvement in a composite measure of nerve function with 600mg/day of oral ALA compared to placebo

Probiotics and Antimicrobial Proteins, 12 (2), 335342