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Thats a mystery facing patients and their doctors these days

Paracetamol (acetaminophen) overdose and hepatotoxicity: mechanism, treatment, prevention measures, and estimates of burden of disease

Transferrin saturation has high biological variability and low sensitivity to detect HFE-related hemochromatosis [108] and a retrospective review of outpatient referrals for elevated serum ferritin found 64% of patients with a serum ferritin threshold over 1000 g/L did not have iron overload on biopsy [109]