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When mitochondrial dysfunction occurs in cells, homeostasis is coordinating by mitophagy which balance a physiological response of mitochondrial biogenesis and clearance of damaged mitochondria (Luo et al., 2020)

Applying products with high-strength vitamin C (L-ascorbic acid) or directly combining them with acids (like almost any AHAs/BHAs) is counterproductive, says Shamban, because the low pH of these acids can degrade the peptides, reducing their efficacy

Patt, L

The self-administered use of complementary and alternative medicine (CAM) supplements and antioxidants in cancer therapy and the critical role of Nrf-2 a systematic review