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J Biol Chem (2018) 293:550921

This is empathized by the decrease of nave B cells and increase of memory B cells in elderlies [358]

Serious deficiency may result in diseases such as beriberi and Wernicke-Korsakoff syndrome

Similarly, in SLE patients, depletion of Faecalibacterium species resulted in diminished butyrate production, attenuating its anti-inflammatory properties and thereby exacerbating both disease progression and inflammatory responses [44]