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Role of gut microbiota in rheumatoid arthritis: potential cellular mechanisms regulated by prebiotic, probiotic, and pharmacological interventions

Helleman, J., et al

Skin Regeneration & Collagen Modulation

Consequently, the toxic effects of cyclophosphamide are likely due to acrolein that, when coupled with the already increased state of inflammation and oxidative stress in cancer, may exacerbate the oxidative state producing ovarian damage both on the level of the follicles and the oocytes