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115 Sterols themselves are poorly absorbed from the diet, but because of their chemical similarity to cholesterol, are thought to compete with cholesterol for absorption in the intestines, which has the net effect of reducing LDL levels

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The drug activates the cyclic guanosine monophosphate-adenosine monophosphate synthase-stimulator of interferon genes (cGASSTING) pathway, 219,220 leading to interferon signaling, upregulation of proinflammatory chemokines (CCL5 and CXCL10), and increased expression of MHC-I and ICD-associated DAMPs