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Conversely, leptin receptor deficient db/db mouse model of type 2 diabetes demonstrated increased BBB permeability, as compared to db/+ control mice (Yu et al., 2019)

However, in cultures of the SEV group, the reduction of CCL3 by B12 did not reach statistical significance and intracellular IL-1B levels were very low, close to the detection limit of the technique, suggesting that, in severe COVID-19, leukocytes are more prone to promptly export IL-1B