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Am J Respir Crit Care Med (1997) 155(2):50612

Levels of adhesion molecules such as intercellular adhesion molecule (ICAM-1/2/ vascular cell adhesion molecules (VCAM)) are increased in ALS

Values remain relatively stable until ages 35 to 40, then begin a significant decline in both amplitude and baseline levels

These rapid effects are particularly important for synaptic plasticity, the strengthening or weakening of synaptic connections that underpins learning and memory [31,32]