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For example, corticosteroids cause weight gain and mood swings

The fairest one-line summary is that DSIP appears to have real biological activity but a weak and inconsistent clinical efficacy signal

infusion of Ang II in dogs at rates chosen to increase renal arterial concentration by only 1015 pg ml, a level that is still within the physiological concentrations of Ang II, markedly reduced sodium excretion, 40 indicating that physiological levels of Ang II are capable of inducing antinatriuretic effects

These drugs, like semaglutide and tirzepatide, have been rigorously tested over years of clinical human trials and have been FDA approved to treat obesity