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M.FischbachS.et al (2018)

yet, as we age, we all experience changes in memory, cognition and brain function

Furthermore, compared to directly targeting LDHA, metabolic interventions aimed at upstream glycolytic regulators may elicit broader biological effects and potential unpredictability ( The aforementioned upstream intervention strategies targeting lactate production and transport offer the advantage of simultaneously reversing microenvironmental acidification and inhibiting lactylation modifications, thereby achieving dual antitumor effects