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Thus, hydrolysis of the amide bond (at position 24) by the bacterial BA hydrolase deconjugates the BA and enables further microbial transformation, including dihydroxylation, oxidation, epimerization of hydroxyl groups, and reconjugation of new AAs to introduce structural diversity (12)

Intratumor heterogeneity and mutations in TP53 , APC , KRAS , and PIK3CA are positively associated with the hyperactivation of hypoxia signaling 45,46

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This property enhances bioavailability in cell culture systems containing serum or purified binding proteins