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Preclinically, FMT from ICI-responding patients reprograms the gut microbiota of germ-free or ATB-treated mice not only by expanding beneficial taxa (e.g., Bacteroides thetaiotaomicron , Faecalibacterium prausnitzii ) but also by restoring critical metabolites: SCFAs (butyrate, acetate) that enhance CD8 + T cell infiltration into the TME and suppress Treg differentiation, and Trp derivatives (IPA) that activate the AhR to boost DC maturation (261, 290, 291)

Notably, leptin may serve as a crucial biological signal for GLP-1, working in synergy, to decrease food intake and body weight

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The SFE + UAE sequence enabled the extraction of phenolic-rich (179.51 mg GAE/g DE) and curcuminoids-rich (604.40 mg/g DE) extracts at temperatures not exceeding 47.5 C