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irritans could be a biomarker for oxidative stress induced by zinc ions

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Chen L., Zhu Y., Hu Z, et al

Indeed, an intrinsic problem with siRNA is that it acts as a Toll-like receptor 3 (TLR3) ligand, and lipid nanoparticle (LNP) formulations cause additional stimulation by cationic lipids of LNP 33,41,42