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Notably, rodents seem to easily develop complications such as mitochondrial damage or oxidative stress-linked hepatocellular apoptosis in response to drug exposure, and this has been easily correlated to mechanisms identified in humans [5254]

doi: 10.3389/fmed.2023.1108623 Received 26 November 2022 Accepted 18 January 2023 Published 13 February 2023 Volume 10 - 2023 Edited by Ayman Grada, Case Western Reserve University, United States Reviewed by Biagio Didona, Istituto Dermopatico dell'Immacolata IDI-IRCCS-Rome, Italy

Collectively, these approaches established a robust framework for understanding how Epitalon may enhance oocyte quality by improving mitochondrial integrity and reducing oxidative stress [2]

S6F), NRF1 and SP1 expression (Fig