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Moreover, QUE triggered lysosomal activation by promoting the nuclear translocation of EB and activating the transcription of lysosomal genes

10.1002/j.1460-2075.1994.tb06418.x 62

Licaj, I

This data suggests that the variants induce a different downstream transcriptional programme in response to metabolic stress, in line with our observation of a significantly reduced expression of the cytokine Ccl2 in starved C3H10T1/2 adipocytes when we overexpressed the R72 compared to the P72 variant