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Human in vivo studies have demonstrated BSS PLUS to be safe and effective when used during surgical procedures such as pars plana vitrectomy, phacoemulsification, cataract extraction/lens aspiration, anterior segment reconstruction

Excess ammonia enhances the activity of ubiquitin ligases, such as E3 ubiquitin ligase, facilitating protein degradation

doi: 10.1016/j.biopha.2020.110554 119 ShanJPengLQianWXieTKangAGaoBet al

the termadministered sequentially, as used herein, may mean that the formulations of the present disclosure and the additional active agent may not be administered at the same time but one after the other, or in groups, with a specific time interval between administrations