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It is yet unclear whether central and peripheral symptoms are linked or develop independently of each other, hence a better understanding of their connections is important

According to the statistics, the incidence of DILI is 1419/100,000 people in Western countries, and it is the most common cause of acute liver failure ( FIGURE 1 Natural products derived from diverse sources, including plants, animals, microorganisms, fermentation products, and marine organisms, exhibit a broad spectrum of biological activities and chemical structures

6 TMAO and other diseases Beyond IBD, TMAOs role in immunometabolism and its involvement in diverse chronic diseases is increasingly recognized ( Figure 3 )

Williamson M, de Winter P, Masters JR