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In this context, it is physiologically relevant that PC synthesis is upregulated upon increase of ApoB-free lumenal LDs, which are normally exported to Golgi but accumulate in the ER when stress mounts

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10.1016/j.bcp.2020.114045 98 DoseB.YalinM.DriesS

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Since these improvements stem from enhanced mitochondrial function, they are likewise constrained by and dependent on the functional reserve of residual intact mitochondria, with the extent of benefit influenced by the patient's genotype

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