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In addition, Ca 2+ signaling, chromatin changes, Wnt signaling, and RNA splicing also play an important role in the pathogenesis of these diseases

The above considerations suggest that two pharmacologically distinct mechanisms with opposite effects on the same signaling pathway are involved in a normally unresolvable physiological failure (complete obstruction (ligation) of vessels and ischemia due to a cause that could be not removed, inadequate rescue and unable to heal)