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Mania The following adverse reactions not listed previously were reported by greater than 1% of Depakote-treated patients and with a greater incidence than placebo in placebo-controlled trials of manic episodes associated with bipolar disorder: Body as a Whole: Chills, chills and fever, drug level increased, neck rigidity

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Three trials included running, either on a treadmill (Reference Duncan, Tallis and Wilson33,Reference Lin, Hsu and Lin37) or as a marathon race (Reference Shanely, Nieman and Zwetsloot31,Reference Ahmed, Henson and Sanderson32) , one trial employed walking on a treadmill in a climate chamber (Reference Timpmann, Hackney and Tamm34) , one trial used rowing ergometry (Reference Skarpanska-Stejnborn, Pilaczynska-Szczesniak and Basta27) and three trials incorporated resistance exercise, including wrist flexion (Reference Walker, Altobelli and Caprihan26) , bench press (Reference Williams, Langley and Roberson38,Reference Liu, Zhao and Yan39) and/or squat exercises (Reference Liu, Zhao and Yan39)

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