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Dynamic remodeling of ECM is a hallmark of skin aging With aging, epidermal thickness decreases rete ridges flatten, and the skins moisturizing and barrier functions are compromised under the influence of gene-regulated cellular senescence 8 , extracellular matrix degradation due to oxidative stress 9 , and remodeling of the extracellular matrix by advanced glycation end products (AGEs) 10,11,12

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( i ) Western blots with anti-H3K4me1 and anti-H3K14ac antibodies

Treatment of restless legs syndrome/Willis-Ekbom disease with the non-selective ENT1/ENT2 inhibitor dipyridamole: testing the adenosine hypothesis