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Medically reviewed by Steven Ganzel, DO, MS on July 20, 2026

The reduction in purine levels was associated with increased oxidative stress and endothelial dysfunction, both of which have been implicated in the pathophysiology of both ME/CFS and GWS (Furuhashi, 2020

This mechanism illustrates the structural selectivity of mitochondrial-lysosomal interactions within the MQC system and offers a complementary pathway to traditional mitophagy, which primarily mediates bulk mitochondrial clearance