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Combination of photodynamic therapy and temozolomide on glioma in a rat C6 glioma model

Indeed, since the 1960s the brain was almost axiomatically viewed as an immune-privileged site [473]

Hyperoxia reportedly impaired microvascular perfusion [60,61,62] and induced a paradoxical reduction in regional oxygen delivery [63] in various clinical situations, although other experimental reports have suggested a beneficial role of hyperoxemia in hemodynamic stabilization and the redistribution of blood flow to important organs [64, 65]