glutathione peroxidase catalytic mechanism - an overview The Selenoprotein Glutathione Peroxidase 4:

Two groups were defined: 60 children with Down syndrome and 29 siblings without Down syndrome

Reproducibility ranged from good to excellent, with (a) three studies at 3T (Bednak et al., 2015, Dhamala et al., 2019, Schubert et al., 2017), one study at 4T (Terpstra et al., 2005) and one study at 7T (van de Bank et al., 2015) reporting good reproducibility, (b) one study at 7T (Reid et al., 2022) reporting excellent reproducibility, and (c) three studies at 3T (Prisciandaro et al., 2020, Wijtenburg et al., 2014, Wijtenburg et al., 2019) and four studies at 7T (Gonen et al., 2020, Lally et al., 2016, Lim and Xin, 2022, Prinsen et al., 2017) reporting good to excellent reproducibility

Peroxidation of lipids disturbs membrane organization, causing functional loss of proteins and DNA, and are found elevated in PD patients where lipid peroxidation adducts contribute to early demise of the SNpc neurons

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