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Research has examined NNMT inhibition and its downstream effects on cellular NAD+ salvage, methylation balance and adipocyte energy metabolism, with preclinical work exploring roles in lipid handling and metabolic regulation

Studies examining safety and tolerability in rodents have generally not reported concerning toxicity signals at doses producing metabolic benefits, though comprehensive toxicology studies and long-term safety data are limited

The authors reported that in obese mice, daily AOD-9604 administration over 14 days produced significant reductions in body weight gain, decreases in adipose tissue mass, and increases in fat oxidation, with effect sizes comparable to those of full-length human growth hormone [1]

Local Coverage Determination Reference The Centers for Medicare & Medicaid Services (CMS) local coverage determination remains the authoritative source for Part B criteria regarding B12 injections