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This paper highlights the importance of geneenvironment interactions in the multistep process required for ALS to manifest clinically

In: Advanced Therapy of Breast Disease

122 Peroxynitrite stimulates TLR4 and NF-B activation and cytokines (release of TNF-, IL-1, and IL-8) 123 , and NOX-induced ROS play a role in inflammasome activation, such as the NLRP3 inflammasome, which drives caspase activity and cytokine production to enhance immune cell recruitment and function