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One of the studies comparing vemurafenib monotherapy and a combination of dabrafenib and trametinib showed a greater 3-year overall rate of survival (11% for monotherapy while 25% for combination)

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Therefore here, we aimed to elucidate (i) the impact of Wnt/-catenin pathway activation on the number of tumour-infiltrating T cells, (ii) the relationship between Wnt/-catenin pathway activation and GC signalling and (iii) the immune-related mechanisms affected by Wnt/-catenin signalling in the tumour microenvironment

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