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24 for the corresponding loop in MPGES1 (denoted C-loop) a direct amino acid interaction to the GSH from this loop was not observed in the MPGES1 X-ray structure (PDB ID: 4AL0) and can neither be found in the MPGES1 structure obtained by 2D-crystallography (PDB ID: 3DWW) 26

Some patients also have nausea diarrhea vomiting constipation early on

mansoni adult worms with 50 M of compounds, or respective controls 5 M Auranofin, 50 M PZQ or 50 M MZM and 0.01% DMSO for 3 h