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The cellular complexity-related features of apoptosis: involvement of organelles Apoptosis is a caspase-dependent RCD which was first described in 1972 based on a characteristic cellular morphology such as cell shrinkage, nuclear condensation, formation of apoptotic bodies, etc [71, 72]

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209,210 Shank3 -knockout mice showed a decrease in the number of corticostriatal connections, 202,211 whereas defects in NMDAR-dependent excitatory neurotransmission and synaptic plasticity have been observed in Shank2 -knockout mice