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High PD-L1 or PD-L2 expression is strongly related to poor outcomes, and this dysregulation strongly impacts signaling pathways such as the mTOR, HIF-1, and ERBB pathways [152]

The formulation was stored at room temperature (25C 2C) and monitored at regular intervals to determine any variations in key characteristics, namely particle size, entrapment efficiency, and polydispersity index (PDI) as shown in Table 7

Cell Death Dis (2021) 12(5):486

Additionally, the release pattern conformed to the Higuchi model as shown in Table 6 and Figure (Supplementary File) ( 3.7 Stability study The stability of the optimized quercetin-loaded niosomal formulation was meticulously evaluated over a 3-month period to assess its robustness and shelf-life under standard storage conditions