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Studies using high-field MRI and postmortem human brain tissues further confirm that excess iron destabilizes the labile iron pool, enhances ROS production via Fenton chemistry, disrupts respiratory chain function, alters bioenergetics, and promotes protein, DNA, and lipid damage through oxidative stress (250, 251)

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[DOI] [PMC free article] [PubMed] [Google Scholar] Goel HL, Mercurio AM