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Moor Inhibition of MMP-3 or -9 suppresses lipopolysaccharide-induced expression of proinflammatory cytokines and iNOS in microglia JNC

2024 Jul 13];21(21):6572-81

As previously discussed, GPX4 expression in myeloid cells (especially macrophages) limits CASP1-CASP11-mediated inflammasome activation and GSDMD-dependent pyroptosis, thereby preventing a cytokine storm and septic death during bacterial infection [33]