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Danons disease (DD) is an X-linked single-gene disease in which vision loss can begin at a young age

Pro-efferocytic nanoparticles are specifically taken up by lesional macrophages and prevent atherosclerosis

The researchers showed that senescent Leydig cell accumulation is a driver of age-related testosterone decline, and that targeted elimination of these cells with FOXO4-DRI restored endocrine function