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There is a concept suggesting that the availability of -EC could become a limiting factor in maintaining necessary cellular GSH levels to efficiently protect against oxidative stress and potential physiological damage

Veilleux-Lemieux D et al (2013): Pharmacokinetics of Ketamine and Xylazine in Young and Old SpragueDawley Rats

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Previous studies have shown that a small molecule called Ras Lethal 3 ((1S,3R)-RSL3,(RSL3)) can pharmacologically inhibit GPX4 in skin and soft tissue cancer models in vitro and leads to induction of ferroptosis 10,11