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[5] It proceeds via acid-base catalysis through a three-step mechanism, involving two strictly conserved amino acid residues, a lysine (Lys) and a glutamate (Glu)

Upon bile acid activation, hepatic FXR induces expression of small heterodimer partner (SHP), which suppresses CYP7A1 and CYP8B1 gene transcription, thereby reducing bile acid synthesis (68)

And they're like, well, first off, we the process of making this cheese is like 4 to 6 hours in the morning every day, and it gets the lactose out, whereas we just slap it in and and send it out, you know, and it's like, that's not it's also raw cheese, you know

This stability profile distinguishes it from many peptide-based research compounds and has contributed to interest in its biochemical persistence, signaling activity, and pathway-specific effects in mechanistic investigations