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There are many adverse effects, ranging from serious ones like hepatotoxicity to minor ones like peripheral neuropathy, joint, pain, visual impairment, nausea, and vomiting (El-Sadr et al., 2001

Recent studies demonstrated that sildenafil exhibited significant efficacy in preventing HAPH

Furthermore, the coordination between the anal sphincters and the pelvic floor muscles is crucial

Once bioavailable, their metabolites are absorbed through the intestinal epithelium and distributed to peripheral tissues, where they can exert functional effects ( Polyphenols are increasingly recognized as prebiotic-like agents, influencing gut microbiota balance and short-chain fatty acid (SCFA) production