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In Vitro DL-Dithiothreitol is widely used in biochemistry works to reduce dissulfide bridges, protect biomolecules, in sample preparation, and to denature proteins before electrophoresis analysis (SDS-PAGE)

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In models of Alzheimer's disease, ANT3 expression is altered in response to amyloid-beta-induced mitochondrial damage, suggesting a role in neuronal energy metabolism and cell fate [206]