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Although it may seem counterintuitive, NRF2 also regulates enzymes involved in heme biosynthesis

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These ABC transporters require a continuous ATP supply in cancer cells

In a mouse model of breast cancer with TNBC cells treated with a TDO2 inhibitor, there was a significant reduction in the number of metastatic lung nodules, indicating that TDO2 enhances the metastatic capacity of TNBC cells (DAmato et al., 2015)