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15,18 These epigenetic alterations lead to metabolic dysregulation, cartilage degradation, and joint dysfunction (Figure 1)

In a transected Achilles tendon model in rats, the Sikiric group reported dose-dependent improvement in functional recovery, biomechanical strength, and histological healing markers compared with saline-treated controls [Sikiric et al., Inflammopharmacology, 2018]

Rather than competing for identical cell receptors, these two compounds complement each other during tissue remodeling assessments

When combined with appropriate testosterone optimization, IGF-1 can amplify the benefits of both therapies