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After 2 h incubation at RT, we detected both apo-VadK at the expected mass/charge (m/z = 50498) and phosphorylated-VadK with an increased mass shift of ~80 Da in accordance with a phosphorylation event (Fig

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C34 and C37 target an immunodominant patch allosterically exposed by E3 dissociation on E2 To circumvent the complexity arising from the compact and crosslinked distribution of Fab molecules on VLP vertices, we determined the monovalent complex structures of C34 and C37 Fab molecules with the E1E2 heterodimer

Table 4 Comparison of the percent of subjects achieving the targeted cumulative busulfan exposure (cAUC) for three different dosing cohorts