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These molecules induce reactions primarily by interaction with receptors for advanced glycation end-products (RAGEs), and exert their toxic effects in the blood vessels, liver and retinas, and can also promote the development of several types of cancer as well as infertility (12,13,21-23)

Similarly, a cross-sectional study from Iran that involved 4,763 adults demonstrated that depressed individuals had a significantly increased risk of constipation, with an adjusted odds ratio (OR) of 1.69 (95% CI: 1.372.09) ( Longitudinally, bidirectional temporal relationships exist between chronic constipation and depression

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(357.5 g), and Stephania tetrandra S.Moore (715 g) are decocted with water and filtered twice