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This forceful action can damage the peptide molecules

10.3390/ph16071020 196

Many registered phase I/II clinical trials designed to investigate the effectiveness of curcumin alone or with first-line treatment in patients with breast, prostate, pancreatic, lung, or colorectal cancer are under way (69)

Additionally, Nrf2 knockout lead to the formation of fibrotic tissues, indicating that Nrf2 is a potential ferroptosis-related therapeutic target and biomarker for evaluating the severity of PF [215]