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The cumulative impact of impaired HPA regulation combined with compromised glucocorticoid and insulin receptor activity, aggravated by inflammatory cytokines, might explain the high rate of metabolic syndrome, diabetes, dyslipidemia, and osteoporosis in the bipolar population (88, 204)

Auranofin Auranofin is an antiarthritic gold phosphine compound that also exhibits anticancer effects similar to those of cisplatin

Summary and Conclusion Melanin hyperpigmented disorders affect a large population in the world and lead to negative impacts on quality of life