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Proc Natl Acad Sci USA 94 (1997): 93669371

Since UBR5 can stably associate with OTUD5 26 , UBR5 may transiently ubiquitylate OTUD5 with K48-linked chains

This leads to the accumulation of mitochondrial reactive oxygen species (mitoROS), which leads to cancer cell death through a process called apoptosis