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While this study did not explicitly demonstrate a causal relationship between peripheral trauma and de novo parkinsonism, it supports the two-hit hypothesis, i.e., in predisposed individuals (first hit), trauma (second hit) results in increased alpha synuclein oligomerization

anti-drug antibodies in about 51% (diabetes) to 64.5% (obesity) of users with no effect on clearance, weight, or HbA1c: FDA Mounjaro NDA 215866 label and Summary Review

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