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PMID: 24717514 View source Ulanovskaya OA, et al

Eur J Pharmacol 1997

Minocycline plus RT enhanced OS by about 140% compared with treatment with RT, while minocycline plus temozolomide improved OS by about 38% compared with monotherapy with temozolomide [153]

Most tumours, including NSCLC, associated with tumour angiogenesis overexpress vascular endothelial growth factors (VEGFs), and VEGF/VEGF receptor (VEGFR) axes, particularly the VEGF-A/VEGFR2 axis, play a pivotal role in angiogenesis (5)