Biological Role of Vitamin B12 Helps make red blood cells Prevents certain types of anemia Keeps nerves protected Supports memory and focus Helps turn food into energy B12 deficiency may lead to fatigue, shortness of breath, nerve damage, memory impairment, mood changes, and irreversible neurological complications if untreated

You should contact your GP or NHS 111 if you experience: Persistent diarrhoea lasting more than 7 days in otherwise healthy adults Blood or mucus in stools , which may indicate inflammatory bowel disease or infection Severe abdominal pain or cramping that is worsening or different from previous digestive symptoms Unexplained weight loss alongside bowel changes Signs of allergic reaction , including rash, itching, swelling, or difficulty breathing (call 999 or go to A&E for severe reactions) Neurological symptoms such as numbness, tingling, balance problems, or memory difficulties, which may indicate B12 deficiency is not being adequately treated Seek help sooner if you have red flag symptoms, are pregnant, immunosuppressed, elderly, or have significant underlying health conditions
Though this is not an interaction in the traditional sense, it is an adjunctive measure that may improve tolerance of NAD+ therapy
PMID: 25998928 Peirong Huang et al