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7.1 Overview of necroptosis Necroptosis represents a distinct form of PCD that combines features of both necrosis and apoptosis

Consequently, the defense axis constituted by GPX4 and GSH is generally considered the core molecular apparatus for cellular resistance to ferroptosis, making it a focal point in OA pathogenesis research and targeted therapy exploration

This happens through increased lipid peroxidation and glycoxidation reactions, which cause more of the reactive products (like methylglyoxal) that bind with proteins to form AGEs.[ref] High blood sugar: More AGEs are also produced when blood sugar levels are high

SOD mimetic removes the products of ROMs that aids in the prevention of tissue damage and cellular energetic failure related with ischemia and perfusion (Salvemini and Cuzzocrea, 2002)