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Once feedback inhibition engages, additional secretagogue dosing has diminishing effect

Proc Natl Acad Sci U S A 94:1116811172 Brodie AE, Reed DJ (1987) Reversible oxidation of glyceraldehyde 3-phosphate dehydrogenase thiols in human lung carcinoma cells by hydrogen peroxide

Nrf2 also promotes the production of heme oxygenase-1 (HO-1) to protect hepatocytes from oxidative stress, and HO-1 attenuates alcohol-induced liver damage by suppressing inflammatory responses [11]