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In addition to genetic factors, prenatal exposure to drugs and environmental toxicants represents a major contributing factor to congenital malformations

the CD8 transmembrane domain can be encoded by the nucleic acid sequence ATCTACATCT GGGCGCCCTT GGCCGGGACT TGTGGGGTCC TTCTCCTGTC ACTGGTTATC ACCCTTTACT GC the transmembrane domain of the CAR can comprise or consist of the CD8a hinge domain

On one hand, STING activation has been shown to promote the differentiation of nave CD4 T cells into Th1 and Th9 cells and enhance the production of effector cytokines such as IFN- and IL-9, thereby augmenting CD4 T cell effector functions [229]

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